ABSTRACT
To assess the serum levels of resistin and HOMA in obese subjects and to evaluate the association of resistin with insulin resistance [HOMA index]. Also to study the effect of weight loss programs on their levels and on body fat mass. Forty-five obese premenopausal females and fifteen healthy ones [serving as a control group] were included. Obese subjects were equally divided into 3 groups [A, B, C] according to the weight loss program. Group A were subjected to diet regimen, Group B to diet regimen and exercise program, and Group C to exercise program only. All studied groups were subjected to full clinical examination, assessment of BML WC, HC, WHR and laboratory investigations including serum resistin and HOMA index. Body fat content was measured by DEXA. Programs of weight loss were carried out for three months, followed by reassessment. There was a significant difference between obese subjects and controls regarding BMI, WC, HC, WHR, Triglycerides, Cholesterol, HDL, LDL, Resistin, TB-FM, Trumk - FM, Leg-FM, Body fat percentage and HOMA index. A highly significant difference was found, in the three groups before and after weight loss regarding all parameters except for WHR which showed significant difference with group B only. Following weight loss, the comparison between the 3 groups together, revealed a significant difference between them with the greatest change being noticed in group B. Also a significant positive correlation was found between BMI and HOMA index. Resistin is believed to be a key factor for obesity, cardiovascular and type II diabetes. The combined program of diet regimen and exercise seems to be the optimal approach for prevention and management of obesity, metabolic and cardiovascular disorders